PrintCarla Oliveira received her Ph.D. in Chemical and Biological Engineering from the University of Minho (UM) in 2009. She developed her Post-Doctoral research activities for 9 years at the Centre of Biological Engineering (UM) in the field of Molecular Biotechnology, with 2 fellowships financed by the FCT (2010-2019). She participated in many scientific projects as team member and was the Principal Investigator of one FCT project (PTDC/AGR-FOR/3090/2012). She (co)-authored 30 scientific publications in refereed international journals, 5 book chapters and over 25 communications in national and international conferences. She also completed the (co)-supervision of several master theses in Biomedical Engineering and Biotechnology. Her research interests are mainly focused in the production of value-added biomolecules in heterologous microbial hosts, including the bacterium Escherichia coli, and the yeast Pichia pastoris and Saccharomyces cerevisiae. She has strong experience in the cultivation of microorganisms in flasks and bioreactors systems, in the purification of recombinant proteins using different separation techniques, and in the structural characterisation and assessment of the biological activities of the purified products. Since 2019, she is Senior Researcher and responsible for the Fermentation Platform at ALCHEMY project. She coordinates Fermentation joint projects with Amyris Inc. US and leads the “Strain Design and Fermentation lab” within the CBQF research group “Fermentation Solutions”.
Publications
Gomes AS, Ramos H, Gomes S, Loureiro JB, Soares J, Barcherini V, Monti P, Fronza G, Oliveira C, et al. 2020. SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations. Biochimica et Biophysica Acta - General Subjects 1864(1), 129440. DOI: 10.1016/j.bbagen.2019.129440
Aguiar TQ, Santos SB, Martins IM, Domingues L, Oliveira C. 2019. Production and bioengineering of recombinant pharmaceuticals. In Proteins: Sustainable Source, Processing and Applications, Chap. 9. Academic Press, pp. 259-293. ISBN: 978-0-12-816695-6
Leal T, Abrunhosa L, Domingues L, Venâncio A, Oliveira C. 2019. BSA-based sample clean-up columns for ochratoxin A determination in wine: method development and validation. Food Chemistry 300, 125204. DOI: 10.1016/j.foodchem.2019.125204
Oliveira C & Domingues L. 2018. Guidelines to reach high-quality purified recombinant proteins. Applied Microbiology and Biotechnology 102, 81-92. DOI: 10.1007/s00253-017-8623-8
Oliveira C, Romaní A, Gomes D, Cunha JT, Gama FM, Domingues L. 2018. Recombinant family 3 carbohydrate-binding module as a new additive for enhanced enzymatic saccharification of whole slurry from autohydrolyzed Eucalyptus globulus wood. Cellulose 25, 2505-2513. DOI: 10.1007/s10570-018-1722-6
Carsanba E, Pintado M, Oliveira C (2021). Fermentation Strategies for Production of Pharmaceutical Terpenoids in Engineered Yeast. Pharmaceuticals, 14(4), 295. DOI: 10.3390/ph14040295
